Fibrolamellar Hepatocellular Carcinoma with Multiple Lung Metastases Treated with Multidisciplinary Therapy

Intern Med. 2018 Dec 15;57(24):3537-3543. doi: 10.2169/internalmedicine.1243-18. Epub 2018 Aug 10.

Abstract

A 20-year old man was diagnosed with fibrolamellar hepatocellular carcinoma (FLHCC) with multiple lung metastases, and chemotherapy with FOLFOX was administered. Contrast enhanced CT after 3 cycles of FOLFOX showed no disease progression. We therefore performed surgical resection and radiofrequency ablation of the liver lesions and lung metastases, after obtaining the patient's informed consent. The liver lesions and lung metastases tested positive for DNAJB1-PRKACA. The treatment for FLHCC with extrahepatic metastasis has not been established; however, in a few cases, good long-term prognoses were obtained with multidisciplinary therapy. We herein report a case of FLHCC with multiple lung metastases that was treated with multidisciplinary therapies.

Keywords: DNAJB1-PRKACA; fibrolamellar hepatocellular carcinoma; multidisciplinary therapy.

Publication types

  • Case Reports

MeSH terms

  • Biopsy
  • Carcinoma, Hepatocellular / diagnosis
  • Carcinoma, Hepatocellular / secondary*
  • Carcinoma, Hepatocellular / therapy
  • Combined Modality Therapy
  • Disease Progression
  • Humans
  • Liver Neoplasms / pathology*
  • Liver Neoplasms / therapy
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / secondary*
  • Lung Neoplasms / therapy
  • Magnetic Resonance Imaging
  • Male
  • Tomography, X-Ray Computed
  • Young Adult

Supplementary concepts

  • Fibrolamellar hepatocellular carcinoma