Ruptured hepatoblastoma successfully treated with cisplatin monochemotherapy: A case report

Mol Clin Oncol. 2018 Aug;9(2):223-225. doi: 10.3892/mco.2018.1643. Epub 2018 Jun 4.

Abstract

Traditionally, ruptured hepatoblastoma is considered a high-risk occurrence, necessitating a chemotherapy regimen usually consisting of cisplatin alternating with carboplatin plus doxorubicin, based on International Childhood Liver Tumours Strategy Group studies. However, ruptured hepatoblastomas with intact hepatic capsules may represent a unique subgroup that may be successfully treated with TAE, cisplatin monotherapy, and surgical excision. We herein present a case of ruptured hepatoblastoma (pretreatment tumor extension stage II) in a 1-year-old female patient that was successfully managed with transarterial embolization (TAE), eight courses of cisplatin chemotherapy and surgical removal. The patient currently remains disease-free for >12 months. Given the rarity of ruptured hepatoblastomas, further study of patients within this subgroup is required to confirm the findings of the present study.

Keywords: chemotherapy; child; ruptured hepatoblastoma; transarterial embolization.