Targeting neurodegeneration to prevent post-traumatic epilepsy

Neurobiol Dis. 2019 Mar:123:100-109. doi: 10.1016/j.nbd.2018.08.006. Epub 2018 Aug 9.

Abstract

In the quest for developing new therapeutic targets for post-traumatic epilepsies (PTE), identifying mechanisms relevant to development and progression of disease is critical. A growing body of literature suggests involvement of neurodegenerative mechanisms in the pathophysiology of acquired epilepsies, including following traumatic brain injury (TBI). In this review, we discuss the potential of some of these mechanisms to be targets for the development of a therapy against PTE.

Keywords: Neurodegeneration; Neuroinflammation; Post-traumatic epilepsy; Tauopathies; Traumatic brain injury; β amyloid.

Publication types

  • Review

MeSH terms

  • Amyloid beta-Peptides / metabolism
  • Amyloid beta-Protein Precursor / metabolism
  • Animals
  • Disease Progression
  • Encephalitis / etiology
  • Encephalitis / physiopathology
  • Epilepsy, Post-Traumatic / complications
  • Epilepsy, Post-Traumatic / physiopathology*
  • Epilepsy, Post-Traumatic / therapy*
  • Humans
  • Neurodegenerative Diseases / physiopathology*
  • Tauopathies / etiology
  • Tauopathies / physiopathology

Substances

  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor