Trans-Ferulic Acid-4-β-Glucoside Alleviates Cold-Induced Oxidative Stress and Promotes Cold Tolerance

Chong Xue; Huanyu Lu; Ying Liu; Jianbin Zhang; Jiye Wang; Wenjing Luo; Wenbin Zhang; Jingyuan Chen

doi:10.3390/ijms19082321

Trans-Ferulic Acid-4-β-Glucoside Alleviates Cold-Induced Oxidative Stress and Promotes Cold Tolerance

Int J Mol Sci. 2018 Aug 8;19(8):2321. doi: 10.3390/ijms19082321.

Authors

Chong Xue¹, Huanyu Lu², Ying Liu³, Jianbin Zhang⁴, Jiye Wang⁵, Wenjing Luo⁶, Wenbin Zhang⁷, Jingyuan Chen⁸

Affiliations

¹ Department of Occupational and Environmental Health, Fourth Military Medical University, Key Laboratory of Hazard Assessment and Control in Special Operational Environment, Ministry of Education, Xi'an 710032, China. xuechong456@fmmu.edu.cn.
² Department of Occupational and Environmental Health, Fourth Military Medical University, Key Laboratory of Hazard Assessment and Control in Special Operational Environment, Ministry of Education, Xi'an 710032, China. luhuanyu66@fmmu.edu.cn.
³ Department of Occupational and Environmental Health, Fourth Military Medical University, Key Laboratory of Hazard Assessment and Control in Special Operational Environment, Ministry of Education, Xi'an 710032, China. liuying2015@fmmu.edu.cn.
⁴ Department of Occupational and Environmental Health, Fourth Military Medical University, Key Laboratory of Hazard Assessment and Control in Special Operational Environment, Ministry of Education, Xi'an 710032, China. zjbin777@fmmu.edu.cn.
⁵ Department of Occupational and Environmental Health, Fourth Military Medical University, Key Laboratory of Hazard Assessment and Control in Special Operational Environment, Ministry of Education, Xi'an 710032, China. wangjiye@fmmu.edu.cn.
⁶ Department of Occupational and Environmental Health, Fourth Military Medical University, Key Laboratory of Hazard Assessment and Control in Special Operational Environment, Ministry of Education, Xi'an 710032, China. luowenj@fmmu.edu.cn.
⁷ Department of Occupational and Environmental Health, Fourth Military Medical University, Key Laboratory of Hazard Assessment and Control in Special Operational Environment, Ministry of Education, Xi'an 710032, China. zwb@fmmu.edu.cn.
⁸ Department of Occupational and Environmental Health, Fourth Military Medical University, Key Laboratory of Hazard Assessment and Control in Special Operational Environment, Ministry of Education, Xi'an 710032, China. jy_chen@fmmu.edu.cn.

Abstract

Trans-ferulic acid-4-β-glucoside (C₁₆H₂₀O₉, TFA-4β-G) is a monomer extracted from the Chinese medicine called radix aconiti carmichaeli (Fuzi). To date, research on this substance is lacking. Here, we found that trans-ferulic acid-4-β-glucoside effectively promoted cold acclimatization in mice via increased heat production and alleviation of oxidative stress in a cold environment. Thus, our work indicates that ferulic acid-4-β-glucoside is a potential therapeutic candidate for prevention and treatment of cold stress injury.

Keywords: brown adipose tissue; cold acclimatization; ferulic acid; oxidative stress.

MeSH terms

Acclimatization / drug effects
Aconitum / metabolism
Adipose Tissue, Brown / drug effects
Adipose Tissue, Brown / physiology
Animals
Cold Temperature / adverse effects
Cold-Shock Response / drug effects*
Cold-Shock Response / physiology
Coumaric Acids / metabolism
Coumaric Acids / therapeutic use
Drugs, Chinese Herbal / metabolism
Drugs, Chinese Herbal / therapeutic use
Glucosides / metabolism*
Glucosides / therapeutic use
Humans
Mice
Oxidative Stress / drug effects*
Thermogenesis / drug effects
Thermogenesis / genetics*

Substances

Coumaric Acids
Drugs, Chinese Herbal
Glucosides
ferulic acid