RETRACTED: Amentoflavone suppresses hepatocellular carcinoma by repressing hexokinase 2 expression through inhibiting JAK2/STAT3 signaling

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief and the authors. Panels from Figures 2B and 3D appear similar to panels from Figure 8b,c of the article published by Shuli Wang and Guanzhen Li in the Naunyn-Schmiedeberg's Archives of Pharmacology (2020) https://doi.org/10.1007/s00210-020-01808-2. Also, panels from Figure 3B appear similar to panels from Figure 3A of the article published by Xiangyang Dou, Meihua Wang, Tao Zhang and Jiapei Yao in the Anatomical Record (2019) https://doi.org/10.1002/ar.24324 and Figure 2A of the article published by Qiang Wang, Yi Yan, Jie Zhang, Peng Guo, Yuqing Xing, Yong Wang, Fawei Qin and Qingyun Zeng in Biomedicine & Pharmacotherapy 104 (2018) 28-35 https://doi.org/10.1016/j.biopha.2018.05.013. In addition, the Vehicle panel from Figure 3D appears similar to the Vehicle panel from Figure 7E of the article published by Xiaoping Pan, Chen Wang, Yan Li, Lida Zhu and Ti Zhang in Life Sciences 214 (2018) 124-135 https://doi.org/10.1016/j.lfs.2018.10.064. Panels from Figure 3E appear similar to panels from Figure 8E of the article published by Luping Wang, Junyu Wang, Hong Zhao, Guoping Jiang, Xiaojie Feng, Wenxia Sui and Hongling Liu in the Naunyn-Schmiedeberg's Archives of Pharmacology 392 (2019) 551–563 https://doi.org/10.1007/s00210-018-01607-w. Although this article was published earlier than most of the other articles, the Editor decided to retract this article given the concerns on the reliability of the data. Also, one of the conditions of submission of a paper for publication is that authors declare explicitly that their work is original. As such this article represents an abuse of the scientific publishing system. The scientific community takes a very strong view on this matter and apologies are offered to readers of the journal that this was not detected during the submission process.

Keywords: AF; Apoptosis; Glycolysis; HCC; HK2; STAT3.