Abstract
A cancer cell-targeting fluorescent sensor has been developed to image mobile Zn2+ by introducing a biotin group. It shows a highly selective response to Zn2+in vitro, no toxicity in cellulo and images 'mobile' Zn2+ specifically in cancer cells. We believe this probe has the potential to help improve our understanding of the role of Zn2+ in the processes of cancer initiation and development.
MeSH terms
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Biotin / analogs & derivatives*
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Biotin / chemical synthesis
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Biotin / pharmacology*
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Biotin / toxicity
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Fluorescence
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / pharmacology*
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Fluorescent Dyes / toxicity
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Humans
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Keratinocytes / drug effects
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Lactams, Macrocyclic / chemical synthesis
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Lactams, Macrocyclic / pharmacology*
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Lactams, Macrocyclic / toxicity
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Ligands
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MCF-7 Cells
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Microscopy, Fluorescence
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Zinc / analysis*
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Zinc / metabolism
Substances
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Fluorescent Dyes
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Lactams, Macrocyclic
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Ligands
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Biotin
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Zinc