Triple-crosslinkedβ-cyclodextrin oligomer self-healing hydrogel showing high mechanical strength, enhanced stability and pH responsiveness

Daham Jeong; Sang-Woo Joo; Vijay Vilas Shinde; Seunho Jung

doi:10.1016/j.carbpol.2018.06.117

Triple-crosslinkedβ-cyclodextrin oligomer self-healing hydrogel showing high mechanical strength, enhanced stability and pH responsiveness

Carbohydr Polym. 2018 Oct 15:198:563-574. doi: 10.1016/j.carbpol.2018.06.117. Epub 2018 Jun 28.

Authors

Daham Jeong¹, Sang-Woo Joo¹, Vijay Vilas Shinde², Seunho Jung³

Affiliations

¹ Department of Bioscience and Biotechnology, Microbial Carbohydrate Resource Bank (MCRB), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, South Korea.
² Institute for Ubiquitous Information Technology and Applications (UBITA), Center for Biotechnology Research in UBITA (CBRU), Konkuk University, Seoul 05029, South Korea.
³ Department of Bioscience and Biotechnology, Microbial Carbohydrate Resource Bank (MCRB), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, South Korea; Institute for Ubiquitous Information Technology and Applications (UBITA), Center for Biotechnology Research in UBITA (CBRU), Konkuk University, Seoul 05029, South Korea. Electronic address: shjung@konkuk.ac.kr.

PMID: 30093035
DOI: 10.1016/j.carbpol.2018.06.117

Abstract

A novel self-healing hydrogel was prepared from a cationic β-cyclodextrin oligomer allyl ether [C(βCD-OM)AE] using a triple cross-linking strategy combining electrostatic interaction, host-guest complexation, and CC bonds as the macrocrosslinker. Here, the C(βCD-OM)AE@Ad gel was successfully prepared by polymerization of synthesized C(βCD-OM)AE, 1-adamantyl acrylate, and acrylic acid. The triple cross-linked hydrogel shows multi-functionality of high mechanical strength, enhanced stability, cytocompatibility, pH responsiveness as well as self-healing ability. Based on the cooperative and synergetic forces of non-covalent and covalent bonds, the C(βCD-OM)AE@Ad gel shows a high tensile strain up to 1,590%, and the self-healed gel could restore up to 84% of its initial length within 24 h. Furthermore, drug release in the hydrogel was controlled by the surrounding pH and slowly released. The present work reveals the cooperativity of multiple cross-links for a 3D structured polymeric material, and the developed self-healable hydrogel can possibly be applied in various biomedical applications.

Keywords: Host-guest interaction; Hydrogel; Ionic interaction; Self-healing; β-Cyclodextrin oligomer.