Abstract
The intracellular pathogen Francisella secretes effector proteins inside host cells; however, their functions have remained unclear. In this issue of Cell Host & Microbe, Ledvina et al. (2018) elucidate the role of one such effector, OpiA, to be a bacterial phosphatidylinositol-3-kinase that alters phagosomal trafficking and can promote intracellular bacterial replication.
Copyright © 2018 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimicrobial Cationic Peptides
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Bacteria
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Bacterial Proteins / metabolism*
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Cytosol / metabolism
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Cytosol / microbiology
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DNA Replication*
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Francisella / genetics
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Francisella / metabolism*
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Francisella / pathogenicity
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Genes, Bacterial / genetics
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Host-Pathogen Interactions / physiology
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Lysosomes
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Macrophages / metabolism
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Macrophages / microbiology
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Mice
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Mutation
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Phagosomes / metabolism*
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Phagosomes / microbiology
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Phosphatidylinositol 3-Kinase / metabolism*
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Protein Transport / physiology*
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Reactive Oxygen Species
Substances
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Antimicrobial Cationic Peptides
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Bacterial Proteins
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Reactive Oxygen Species
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Phosphatidylinositol 3-Kinase