Bacterial Prison Break: A Host Protein Mimic Paves the Way

Cell Host Microbe. 2018 Aug 8;24(2):189-191. doi: 10.1016/j.chom.2018.07.016.

Abstract

The intracellular pathogen Francisella secretes effector proteins inside host cells; however, their functions have remained unclear. In this issue of Cell Host & Microbe, Ledvina et al. (2018) elucidate the role of one such effector, OpiA, to be a bacterial phosphatidylinositol-3-kinase that alters phagosomal trafficking and can promote intracellular bacterial replication.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimicrobial Cationic Peptides
  • Bacteria
  • Bacterial Proteins / metabolism*
  • Cytosol / metabolism
  • Cytosol / microbiology
  • DNA Replication*
  • Francisella / genetics
  • Francisella / metabolism*
  • Francisella / pathogenicity
  • Genes, Bacterial / genetics
  • Host-Pathogen Interactions / physiology
  • Lysosomes
  • Macrophages / metabolism
  • Macrophages / microbiology
  • Mice
  • Mutation
  • Phagosomes / metabolism*
  • Phagosomes / microbiology
  • Phosphatidylinositol 3-Kinase / metabolism*
  • Protein Transport / physiology*
  • Reactive Oxygen Species

Substances

  • Antimicrobial Cationic Peptides
  • Bacterial Proteins
  • Reactive Oxygen Species
  • Phosphatidylinositol 3-Kinase