Sweet Killers: NK Cells Need Glycolysis to Kill Tumors

Batya Isaacson; Ofer Mandelboim

doi:10.1016/j.cmet.2018.07.008

Sweet Killers: NK Cells Need Glycolysis to Kill Tumors

Cell Metab. 2018 Aug 7;28(2):183-184. doi: 10.1016/j.cmet.2018.07.008.

Authors

Batya Isaacson¹, Ofer Mandelboim²

Affiliations

¹ The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, Hebrew University Medical School, IMRIC, Jerusalem, Israel.
² The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, Hebrew University Medical School, IMRIC, Jerusalem, Israel. Electronic address: oferm@ekmd.huji.ac.il.

PMID: 30089237
DOI: 10.1016/j.cmet.2018.07.008

Abstract

Natural killer (NK) cells are cytotoxic innate lymphocytes that play a major role in the immune battle against cancer. In this issue of Cell Metabolism, Cong et al. (2018) demonstrate that progressing tumors reduce NK cell glycolytic capacity, which leads to reduced cytotoxicity and an overall dysfunctional NK phenotype.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cytotoxicity, Immunologic*
Disease Progression
Glycolysis
Humans
Killer Cells, Natural
Lung Neoplasms*