Survival analysis for male ductal and lobular breast cancer patients with different stages

Future Oncol. 2019 Jan;15(2):167-180. doi: 10.2217/fon-2018-0455. Epub 2018 Aug 8.

Abstract

Aim: We aimed to investigate risk factors and current treatment effects in male breast cancer patients.

Methods: Kaplan-Meier plot, log-rank test, COX model, nomograms and propensity score matching were used.

Results: Among stage I-III patients, surgery was associated with better prognosis. In subgroup analysis, performing surgery and no radiation or chemotherapy led to worse prognosis in research group. Among stage IV patients, chemotherapy correlated with better prognosis and radiation led to better breast cancer-specific survival. In addition, brain and liver metastasis correlated with worse prognosis; and lung correlated with worse breast cancer-specific survival.

Conclusion: For stage I-III patients, surgery and chemotherapy were recommended. And not applying radiation or chemotherapy could be carefully considered for ER(+) HER-2(-) patients. For stage IV patients, chemotherapy and radiation were commended.

Keywords: ER; HER-2; PR; male breast cancer; metastasis sites; nomograms; prognosis.

Publication types

  • Validation Study

MeSH terms

  • Breast / pathology
  • Breast / surgery
  • Breast Neoplasms, Male / mortality*
  • Breast Neoplasms, Male / pathology
  • Breast Neoplasms, Male / therapy
  • Carcinoma, Ductal, Breast / mortality*
  • Carcinoma, Ductal, Breast / pathology
  • Carcinoma, Ductal, Breast / therapy
  • Carcinoma, Lobular / mortality*
  • Carcinoma, Lobular / pathology
  • Carcinoma, Lobular / therapy
  • Chemoradiotherapy / methods
  • Follow-Up Studies
  • Humans
  • Male
  • Mastectomy / methods
  • Middle Aged
  • Neoplasm Grading
  • Neoplasm Staging
  • Nomograms*
  • Palliative Care / methods
  • Patient Selection*
  • Receptor, ErbB-2 / metabolism
  • Receptors, Estrogen / metabolism
  • Risk Factors
  • SEER Program / statistics & numerical data
  • Survival Analysis
  • Treatment Outcome

Substances

  • Receptors, Estrogen
  • ERBB2 protein, human
  • Receptor, ErbB-2