Maslinic acid as an effective anticancer agent

Cell Mol Biol (Noisy-le-grand). 2018 Jul 30;64(10):87-91.

Abstract

Maslinic acid (2α,3β-dihydroxyolean-12-en-28-oic acid) is a naturally occurring pentacyclic triterpenic compound. Maslinic acid is gradually gaining attention as an excellent pharmacologically active product because of its premium biological properties. In this review we will focus on chemopreventive properties of Maslinic acid against different cancers. Seemingly, available data is limited and we have yet to unravel how Maslinic acid therapeutically targeted oncogenic cell signal transduction cascades in different cancers. Moreover, there are visible knowledge gaps about the ability of Maslinic acid to modulate oncogenic and tumor suppressor microRNAs in various cancers.

Keywords: Apoptosis; Cancer; Maslinic Acid.; Signaling.

Publication types

  • Review

MeSH terms

  • Animals
  • Anticarcinogenic Agents / pharmacology*
  • Anticarcinogenic Agents / therapeutic use
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Apoptosis / drug effects
  • Gene Expression Regulation, Neoplastic / drug effects
  • Humans
  • MicroRNAs / genetics
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Neoplasms / prevention & control*
  • Protein Interaction Maps / drug effects
  • Signal Transduction / drug effects
  • Triterpenes / pharmacology*
  • Triterpenes / therapeutic use

Substances

  • Anticarcinogenic Agents
  • Antineoplastic Agents
  • MicroRNAs
  • Triterpenes
  • maslinic acid