Exploiting natural regulation

Elife. 2018 Aug 6:7:e39664. doi: 10.7554/eLife.39664.

Author

Catherine Proenza^{1

2}

Affiliations

¹ Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, United States.
² Department of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, United States.

Abstract

Using a short peptide to regulate the activity of HCN ion channels illustrates how physiological modulators could inspire new drugs.

Keywords: HCN channels; TRIP8b; allosteric regulation; cAMP; cardiac pacemaker; molecular biophysics; mouse; structural biology.

© 2018, Proenza.

Publication types

Comment

MeSH terms

Cyclic Nucleotide-Gated Cation Channels*
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels*

Substances

Cyclic Nucleotide-Gated Cation Channels
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

Grants and funding

R01 HL088427/HL/NHLBI NIH HHS/United States