Coordination capacity of cytosine, adenine and derivatives towards open-paddlewheel diruthenium compounds

J Inorg Biochem. 2018 Oct:187:109-115. doi: 10.1016/j.jinorgbio.2018.06.010. Epub 2018 Jun 30.

Abstract

[Ru2Cl2(DPhF)3] (DPhF = diphenylformamidinate) links preferentially to the junctions of RNA (ribonucleic acid) structures, although the bonding mode is not known. In order to clarify this question the reactions between [Ru2Cl2(DPhF)3] and cytosine (Hcyto), cytidine (Hcyti), cytidine 2',3'-cyclic monophosphate sodium salt (NacCMP), adenine (Hade), adenosine (Haden) and adenosine 3',5'-cyclic monophosphate (HcAMP) have been carried out. In the resultant complexes, cyto (cytosinate), cyti (cytidinate), cCMP (cytidine 2',3'-cyclic monophosphate monoanion), ade (adeninate), aden (adenosinate) and cAMP (deprotonated adenosine 3',5'-cyclic monophosphate) are bonded to the diruthenium unit as N,N'-bridging ligands, as confirmed by the solution of the crystal structures of [RuCl(DPhF)3(cyto)] and [RuCl(DPhF)3(ade)] by X-ray diffraction. The axial positions of the diruthenium species are still available for additional interactions with other residues that could explain its preference towards RNA junctions.

Keywords: Diruthenium compounds; Nucleobases; Nucleosides; Nucleotides; Open-paddlewheel complexes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenine* / analogs & derivatives
  • Adenine* / chemistry
  • Coordination Complexes / chemical synthesis*
  • Coordination Complexes / chemistry*
  • Cytosine* / analogs & derivatives
  • Cytosine* / chemistry
  • Ruthenium / chemistry*

Substances

  • Coordination Complexes
  • Ruthenium
  • Cytosine
  • Adenine