Pre-clinical evaluation of second generation PIM inhibitors for the treatment of T-cell acute lymphoblastic leukemia and lymphoma

Haematologica. 2019 Jan;104(1):e17-e20. doi: 10.3324/haematol.2018.199257. Epub 2018 Aug 3.

Renate De Smedt^{1

2}, Sofie Peirs^{1

2}, Julie Morscio^{1

2}, Filip Matthijssens^{1

2}, Juliette Roels^{1

2

3}, Lindy Reunes^{1

2}, Beatrice Lintermans^{1

2}, Steven Goossens^{1

2

4}, Tim Lammens^{2

5}, Nadine Van Roy^{1

2}, Aurore Touzart⁶, Silvia Jenni⁷, Yi-Chien Tsai⁷, Federica Lovisa⁸, Lara Mussolin⁸, Valentina Serafin⁸, Filip Van Nieuwerburgh⁹, Dieter Deforce⁹, Anne Uyttebroeck^{10

11}, Thomas Tousseyn¹², Birgit Burkhardt¹³, Wolfram Klapper¹⁴, Barbara De Moerloose^{2

5}, Yves Benoit^{2

5}, Elizabeth Macintyre⁶, Jean-Pierre Bourquin⁷, Giuseppe Basso⁸, Benedetta Accordi⁸, Beat Bornhauser⁷, Jules Meijerink¹⁵, Peter Vandenberghe^{16

17}, Pieter Van Vlierberghe^{18

2}

¹ Department of Biomolecular Medicine, Ghent University, Belgium.
² Cancer Research Institute Ghent (CRIG), Belgium.
³ Diagnostic Sciences, Ghent University, Belgium.
⁴ Molecular and Cellular Oncology Lab, Department for Biomedical Molecular Biology, Ghent University, Belgium.
⁵ Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Belgium.
⁶ Department of Hematology, APHP-Hôpital Necker, Paris, France.
⁷ Department of Oncology, and Children's Research Center, University Children's Hospital Zurich, Switzerland.
⁸ Department of Woman's and Child's Health, Hematology-Oncology Laboratory, Istituto di Ricerca Pediatrica (IRP) and University of Padova, Italy.
⁹ Laboratory of Pharmaceutical Biotechnology, Ghent University, Belgium.
¹⁰ Department of Pediatric Hematology-Oncology, University Hospitals Leuven, Belgium.
¹¹ Department of Oncology, KU Leuven, Belgium.
¹² Translational Cell and Tissue Research laboratory, KU Leuven, Belgium.
¹³ Department of Pediatric Hematology and Oncology, University of Münster, Germany.
¹⁴ Department of Pathology, Hematopathology Section, UKSH Campus Kiel, Germany.
¹⁵ The Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
¹⁶ Department of Hematology, University Hospitals Leuven, Belgium.
¹⁷ Center for Human Genetics, KU Leuven, Belgium.
¹⁸ Department of Biomolecular Medicine, Ghent University, Belgium pieter.vanvlierberghe@ugent.be.

No abstract available

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