MACROD2, an Original Cause of CIN?

Cancer Discov. 2018 Aug;8(8):921-923. doi: 10.1158/2159-8290.CD-18-0674.

Abstract

The fundamental cause of chromosomal instability in colorectal cancer remains elusive. Genetic deletions of the MACROD2 tumor suppressor could play a major role. Cancer Discov; 8(8); 921-3. ©2018 AACRSee related article by Sakthianandeswaren et al., p. 988.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Chromosomal Instability
  • Colorectal Neoplasms / genetics*
  • DNA Repair Enzymes
  • Genes, Tumor Suppressor
  • Haploinsufficiency*
  • Humans
  • Hydrolases
  • Poly (ADP-Ribose) Polymerase-1

Substances

  • MACROD2 protein, human
  • PARP1 protein, human
  • Poly (ADP-Ribose) Polymerase-1
  • Hydrolases
  • DNA Repair Enzymes