Abstract
The fundamental cause of chromosomal instability in colorectal cancer remains elusive. Genetic deletions of the MACROD2 tumor suppressor could play a major role. Cancer Discov; 8(8); 921-3. ©2018 AACRSee related article by Sakthianandeswaren et al., p. 988.
©2018 American Association for Cancer Research.
Publication types
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Research Support, N.I.H., Extramural
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Comment
MeSH terms
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Chromosomal Instability
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Colorectal Neoplasms / genetics*
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DNA Repair Enzymes
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Genes, Tumor Suppressor
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Haploinsufficiency*
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Humans
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Hydrolases
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Poly (ADP-Ribose) Polymerase-1
Substances
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MACROD2 protein, human
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PARP1 protein, human
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Poly (ADP-Ribose) Polymerase-1
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Hydrolases
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DNA Repair Enzymes