Acellular and cellular approaches to improve diabetic wound healing

Hongkwan Cho; Michael R Blatchley; Elia J Duh; Sharon Gerecht

doi:10.1016/j.addr.2018.07.019

Acellular and cellular approaches to improve diabetic wound healing

Adv Drug Deliv Rev. 2019 Jun:146:267-288. doi: 10.1016/j.addr.2018.07.019. Epub 2018 Aug 1.

Authors

Hongkwan Cho¹, Michael R Blatchley², Elia J Duh¹, Sharon Gerecht³

Affiliations

¹ Wilmer Ophthalmologic Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
² Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, Johns Hopkins University Baltimore, MD, USA.
³ Department of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, Johns Hopkins University Baltimore, MD, USA. Electronic address: gerecht@jhu.edu.

PMID: 30075168
DOI: 10.1016/j.addr.2018.07.019

Abstract

Chronic diabetic wounds represent a huge socioeconomic burden for both affected individuals and the entire healthcare system. Although the number of available treatment options as well as our understanding of wound healing mechanisms associated with diabetes has vastly improved over the past decades, there still remains a great need for additional therapeutic options. Tissue engineering and regenerative medicine approaches provide great advantages over conventional treatment options, which are mainly aimed at wound closure rather than addressing the underlying pathophysiology of diabetic wounds. Recent advances in biomaterials and stem cell research presented in this review provide novel ways to tackle different molecular and cellular culprits responsible for chronic and nonhealing wounds by delivering therapeutic agents in direct or indirect ways. Careful integration of different approaches presented in the current article could lead to the development of new therapeutic platforms that can address multiple pathophysiologic abnormalities and facilitate wound healing in patients with diabetes.

Keywords: Cell therapy; Diabetic wound healing; Scaffolds; Tissue engineering.

Publication types

Review

MeSH terms

Animals
Cell- and Tissue-Based Therapy*
Diabetes Mellitus / therapy*
Drug Delivery Systems
Humans
Hypoglycemic Agents / therapeutic use*
Tissue Engineering
Wound Healing / drug effects*

Substances

Hypoglycemic Agents