Brain space and time in mental disorders: Paradigm shift in biological psychiatry

Int J Psychiatry Med. 2019 Jan;54(1):53-63. doi: 10.1177/0091217418791438. Epub 2018 Aug 3.

Abstract

Contemporary psychiatry faces serious challenges because it has failed to incorporate accumulated knowledge from basic neuroscience, neurophilosophy, and brain-mind relation studies. As a consequence, it has limited explanatory power, and effective treatment options are hard to come by. A new conceptual framework for understanding mental health based on underlying neurobiological spatial-temporal mechanisms of mental disorders (already gained by the experimental studies) is beginning to emerge.

Keywords: DSM-5; brain; electroencephalogram; functional connectivity; mental disorders; metastable balance; nested hierarchy; neuronal assemblies.

Publication types

  • Review

MeSH terms

  • Biological Psychiatry / methods*
  • Diagnostic and Statistical Manual of Mental Disorders
  • Diffusion of Innovation
  • Humans
  • Mental Disorders* / physiopathology
  • Mental Disorders* / psychology
  • Mental Disorders* / therapy
  • Neurosciences / methods*
  • Psychiatry / trends*