Continuous monitoring devices and seizure patterns by glucose, time and lateralized seizure onset

Katie M Kinnear; Nicole M Warner; Alan M Haltiner; Michael J Doherty

doi:10.1016/j.ebcr.2018.03.001

Continuous monitoring devices and seizure patterns by glucose, time and lateralized seizure onset

Epilepsy Behav Case Rep. 2018 Mar 21:10:65-70. doi: 10.1016/j.ebcr.2018.03.001. eCollection 2018.

Authors

Katie M Kinnear¹, Nicole M Warner¹, Alan M Haltiner¹, Michael J Doherty¹

Affiliation

¹ Swedish Epilepsy Center, Seattle, WA, USA.

Abstract

Objectives: To investigate if glucose levels influence seizure patterns.

Materials and methods: In a patient with RNS/NeuroPace implanted bi-temporally and type 1 diabetes mellitus, seizure event times and onset locations were matched to continuous tissue glucose.

Results: Left focal seizure (LFS, n = 22) glucoses averaged 169 mg/dL, while right focal seizure (RFS, n = 23) glucoses averaged 131 mg/dL (p = 0.03). LFS occurred at mean time 17:02 while RFS occurred at 04:23. LFS spread to the contralateral side (n = 19) more than RFS (n = 2).

Conclusion: Seizure onset laterality and spread vary with glucose and time of seizure.

Keywords: Circadian; Glucose; Hypometabolism; Insulin; Nonketotic; Stimulation.

Publication types

Case Reports