Synthesis and characterization of salen-Ti(IV) complex and application in the controllable polymerization of D, L-lactide

PLoS One. 2018 Aug 2;13(8):e0201054. doi: 10.1371/journal.pone.0201054. eCollection 2018.

Abstract

Poly(lactic acid) has been extensively investigated in the biomedical field because of its good biocompatibility and biodegradability. As an important method of poly(lactic acid) synthesis, metal complex-catalyzed ring-opening polymerization (ROP) of lactide can achieve a controllable lactide polymerization through the selection of appropriate ligands and metals. In this study, a novel metal (LTi-O)2 complex was synthesized and structurally characterized. (LTi-O)2 showed a relatively high catalytic activity and controllability of Poly(D, L-lactide) (PDLLA) molecular weights (polydispersity index of 1.02-1.22) in the ROP of D,L-lactide. The kinetic equation of D,L-LA ROP catalyzed by (LTi-O)2 could be expressed as-d[M]/dt = k[M]2[(LTi-O)2]1, and the reaction activation energy was 95.67 kJ·mol-1. Physical/chemical properties and biocompatibility evaluation results showed that PDLLA obtained through the (LTi-O)2-catalyzed ROP of D,L- lactide exhibited a good degradation performance and excellent biocompatibility.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry
  • Catalysis
  • Cell Proliferation
  • Coordination Complexes / chemistry*
  • Dioxanes / chemistry*
  • Ethylenediamines / chemistry*
  • Hydrogen-Ion Concentration
  • Kinetics
  • Materials Testing
  • Molecular Weight
  • Osteoblasts / cytology
  • Polyesters / chemistry*
  • Polymerization
  • Rats, Wistar
  • Temperature
  • Titanium / chemistry*
  • Water / chemistry

Substances

  • Biocompatible Materials
  • Coordination Complexes
  • Dioxanes
  • Ethylenediamines
  • Polyesters
  • Water
  • titanium dioxide
  • poly(lactide)
  • disalicylaldehyde ethylenediamine
  • dilactide
  • Titanium

Grants and funding

This work was supported by the National Natural Science Foundation of China (Project No.21477010) and Open Fund of Chongqing Key Laboratory of Industrial Fermentation Microorganism (Chongqing University of Science and Technology) (Project No. LIFM201709). Baojun Yang is employed by Chongqing Huashu Robotics Co., Ltd. The work of this paper is also supported by the Chongqing Science and Technology Commission Project (Project No. cstc2018jcyjAX0699). Chongqing Huashu Robotics Co., Ltd. provided support in the form of salary for author BY, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific role of this author is articulated in the ‘author contributions’ section.