Abstract
A matrix metalloproteinase (MMP) targeted tetrapeptide vesicle has been designed and developed, which strongly binds at a MMP9 enzymatic site. Interestingly, it has a propensity to encapsulate and deliver the doxorubicin drug specifically to the cancer cell, induces superior apoptotic death, and inhibits the metastatic cancer cell migration and growth of multicellular 3D spheroids.
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
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Amino Acid Sequence
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects
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Cell Line, Tumor
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Cell Movement / drug effects
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Doxorubicin / pharmacology*
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Drug Carriers / chemical synthesis
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Drug Carriers / chemistry*
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Humans
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Ligands
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Matrix Metalloproteinase 9 / metabolism*
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Molecular Docking Simulation
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Oligopeptides / chemical synthesis
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Oligopeptides / chemistry*
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Spheroids, Cellular / drug effects
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Antineoplastic Agents
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Drug Carriers
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Ligands
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Oligopeptides
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Doxorubicin
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Matrix Metalloproteinase 9