Sydowianumols A, B, and C, Three New Compounds from Discomycete Poculum pseudosydowianum

Chem Pharm Bull (Tokyo). 2018;66(8):826-829. doi: 10.1248/cpb.c18-00264.

Abstract

Three new compounds, sydowianumols A (1), B (2), and C (3), were isolated from culture broth and mycelial extracts of Poculum pseudosydowianum (TNS-F-57853), an endophytic fungus isolated from fresh leaves of Quercus crispula. The structures of new compounds 1-3 were elucidated from spectroscopic data. Sydowianumols A (1) and B (2) exhibited antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) with 90% minimum inhibitory concentration (MIC90) values of 12.5 µg/mL.

Keywords: Poculum pseudosydowianum; Quercus crispula; antimicrobial activity; endophytic fungus; methicillin-resistant Staphylococcus aureus (MRSA); sydowianumol.

MeSH terms

  • Aldehydes / chemistry*
  • Aldehydes / isolation & purification
  • Aldehydes / pharmacology
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology
  • Ascomycota / chemistry*
  • Humans
  • Methicillin-Resistant Staphylococcus aureus / drug effects
  • Microbial Sensitivity Tests
  • Plant Leaves / microbiology
  • Polyketides / chemistry*
  • Polyketides / isolation & purification
  • Polyketides / pharmacology
  • Quercus / microbiology*

Substances

  • Aldehydes
  • Anti-Bacterial Agents
  • Polyketides
  • aurocitrin