Abstract
The term electroceutical has been used to describe implanted devices that deliver electrical stimuli to modify biological function. Herein, we describe a new concept in electroceuticals, demonstrating for the first time the electrochemical activation of metal-based prodrugs. This is illustrated by the controlled activation of Pt(iv) prodrugs into their active Pt(ii) forms within a cellular context allowing selectivity and control of where, when and how much active drug is generated.
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects
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Coordination Complexes / chemical synthesis
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Coordination Complexes / chemistry
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Coordination Complexes / pharmacology*
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Electrochemical Techniques / methods*
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Electrodes
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HCT116 Cells
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Humans
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Organoplatinum Compounds / chemical synthesis
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Organoplatinum Compounds / chemistry
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Organoplatinum Compounds / pharmacology*
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Oxidation-Reduction
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Prodrugs / chemical synthesis
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Prodrugs / chemistry
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Prodrugs / pharmacology*
Substances
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Antineoplastic Agents
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Coordination Complexes
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Organoplatinum Compounds
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Prodrugs