Catalytic Alkyne Arylation Using Traceless Directing Groups

Angew Chem Int Ed Engl. 2018 Oct 8;57(41):13598-13602. doi: 10.1002/anie.201804955. Epub 2018 Sep 11.

Abstract

By using Pd0 /Mandyphos, we achieved a three-component aminoarylation of alkynes to generate enamines, which are then hydrolyzed to either α-arylphenones or α,α-diarylketones. This Pd-catalyzed method overcomes established known pathways to enable the use of amines as traceless directing groups for C-C bond formation.

Keywords: alkynes; aminoarylation; multicomponent coupling; palladium; regiocontrol.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alkynes / chemistry*
  • Catalysis
  • Hydrolysis
  • Molecular Structure
  • Palladium / chemistry

Substances

  • Alkynes
  • Palladium