By using Pd0 /Mandyphos, we achieved a three-component aminoarylation of alkynes to generate enamines, which are then hydrolyzed to either α-arylphenones or α,α-diarylketones. This Pd-catalyzed method overcomes established known pathways to enable the use of amines as traceless directing groups for C-C bond formation.
Keywords: alkynes; aminoarylation; multicomponent coupling; palladium; regiocontrol.
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.