Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants

Protein Cell. 2018 Sep;9(9):814-819. doi: 10.1007/s13238-018-0568-x.

Lei Yang¹, Xiaohui Zhang¹, Liren Wang¹, Shuming Yin¹, Biyun Zhu¹, Ling Xie¹, Qiuhui Duan¹, Huiqiong Hu^{1

2}, Rui Zheng³, Yu Wei¹, Liangyue Peng^{1

4}, Honghui Han⁵, Jiqin Zhang¹, Wenjuan Qiu³, Hongquan Geng³, Stefan Siwko⁶, Xueli Zhang^{1

2}, Mingyao Liu^{1

6}, Dali Li⁷

¹ East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, China.
² Fengxian Hospital Affiliated to Southern Medical University, Shanghai, 201499, China.
³ Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
⁴ School of Life Sciences, Hunan Normal University, Changsha, 410081, China.
⁵ Bioray Laboratories Inc., Shanghai, 200241, China.
⁶ Department of Molecular and Cellular Medicine, The Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, TX, 77030, USA.
⁷ East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, China. dlli@bio.ecnu.edu.cn.

No abstract available

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