Effective and precise adenine base editing in mouse zygotes

Puping Liang; Hongwei Sun; Xiya Zhang; Xiaowei Xie; Jinran Zhang; Yaofu Bai; Xueling Ouyang; Shengyao Zhi; Yuanyan Xiong; Wenbin Ma; Dan Liu; Junjiu Huang; Zhou Songyang

doi:10.1007/s13238-018-0566-z

Effective and precise adenine base editing in mouse zygotes

Protein Cell. 2018 Sep;9(9):808-813. doi: 10.1007/s13238-018-0566-z.

Authors

Puping Liang^{1

2}, Hongwei Sun³, Xiya Zhang³, Xiaowei Xie³, Jinran Zhang³, Yaofu Bai³, Xueling Ouyang³, Shengyao Zhi³, Yuanyan Xiong³, Wenbin Ma³, Dan Liu⁴, Junjiu Huang^{5

6

7}, Zhou Songyang^{8

9

10

11}

Affiliations

¹ Key Laboratory of Gene Engineering of the Ministry of Education, Guangzhou Key Laboratory of Healthy Aging Research and SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China. liangpp5@mail.sysu.edu.cn.
² Key Laboratory of Reproductive Medicine of Guangdong Province, School of Life Sciences and the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510275, China. liangpp5@mail.sysu.edu.cn.
³ Key Laboratory of Gene Engineering of the Ministry of Education, Guangzhou Key Laboratory of Healthy Aging Research and SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China.
⁴ Verna and Marrs Mclean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
⁵ Key Laboratory of Gene Engineering of the Ministry of Education, Guangzhou Key Laboratory of Healthy Aging Research and SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China. hjunjiu@mail.sysu.edu.cn.
⁶ Key Laboratory of Reproductive Medicine of Guangdong Province, School of Life Sciences and the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510275, China. hjunjiu@mail.sysu.edu.cn.
⁷ State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China. hjunjiu@mail.sysu.edu.cn.
⁸ Key Laboratory of Gene Engineering of the Ministry of Education, Guangzhou Key Laboratory of Healthy Aging Research and SYSU-BCM Joint Research Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, China. songyanz@mail.sysu.edu.cn.
⁹ Key Laboratory of Reproductive Medicine of Guangdong Province, School of Life Sciences and the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510275, China. songyanz@mail.sysu.edu.cn.
¹⁰ State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China. songyanz@mail.sysu.edu.cn.
¹¹ Verna and Marrs Mclean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA. songyanz@mail.sysu.edu.cn.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adenine*
Animals
Gene Editing*
Mice
Zygote / metabolism*

Substances

Adenine