The secrets of the stability of the HIV-1 capsid

Martin Obr; Hans-Georg Kräusslich

doi:10.7554/eLife.38895

The secrets of the stability of the HIV-1 capsid

Elife. 2018 Jul 31:7:e38895. doi: 10.7554/eLife.38895.

Authors

Martin Obr¹, Hans-Georg Kräusslich¹

Affiliation

¹ Center of Infectious Diseases, Heidelberg University, Heidelberg, Germany.

Abstract

Structural and biophysical studies help to follow the disassembly of the HIV-1 capsid in vitro, and reveal the role of a small molecule called IP6 in regulating capsid stability.

Keywords: CA lattice; HIV-1; IP6; PF74; R18 pore; capsid; human; infectious disease; microbiology; molecular biophysics; structural biology; virus.

Publication types

Comment

MeSH terms

Anti-HIV Agents
Capsid Proteins
Capsid*
HIV-1*
Models, Molecular
Phenylalanine

Substances

Anti-HIV Agents
Capsid Proteins
Phenylalanine