Curcumin Effectively Rescued Parkinson's Disease-Like Phenotypes in a Novel Drosophila melanogaster Model with dUCH Knockdown

Oxid Med Cell Longev. 2018 Jul 3:2018:2038267. doi: 10.1155/2018/2038267. eCollection 2018.

Abstract

The relationship between oxidative stress and neurodegenerative diseases has been extensively examined, and antioxidants are considered to be a promising approach for decelerating disease progression. Parkinson's disease (PD) is a common neurodegenerative disorder and affects 1% of the population over 60 years of age. A complex combination of genetic and environmental factors contributes to the pathogenesis of PD. However, since the onset mechanisms of PD have not yet been elucidated in detail, difficulties are associated with developing effective treatments. Curcumin has been reported to have neuroprotective properties in PD models induced by neurotoxins or genetic factors such as α-synuclein, PINK1, DJ-1, and LRRK2. In the present study, we investigated the effects of curcumin in a novel Drosophila model of PD with knockdown of dUCH, a homolog of human UCH-L1. We found that dopaminergic neuron-specific knockdown of dUCH caused impaired movement and the loss of dopaminergic neurons. Furthermore, the knockdown of dUCH induced oxidative stress while curcumin decreased the ROS level induced by this knockdown. In addition, dUCH knockdown flies treated with curcumin had improved locomotive abilities and less severe neurodegeneration. Taken together, with studies on other PD models, these results strongly suggest that treatments with curcumin are an appropriate therapy for PD related to oxidative stress.

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Curcumin / therapeutic use*
  • Drosophila / drug effects
  • Drosophila / metabolism
  • Drosophila melanogaster
  • Male
  • Neuroprotective Agents / therapeutic use*
  • Oxidative Stress / drug effects
  • Parkinson Disease / drug therapy*
  • Parkinson Disease / metabolism*
  • Reactive Oxygen Species / metabolism
  • Ubiquitin Thiolesterase / deficiency*
  • Ubiquitin Thiolesterase / genetics

Substances

  • Neuroprotective Agents
  • Reactive Oxygen Species
  • Ubiquitin Thiolesterase
  • Curcumin