Magnetic field-inducible drug-eluting nanoparticles for image-guided thermo-chemotherapy

Guru Karthikeyan Thirunavukkarasu; Kondareddy Cherukula; Hwangjae Lee; Yong Yeon Jeong; In-Kyu Park; Jae Young Lee

doi:10.1016/j.biomaterials.2018.07.028

Magnetic field-inducible drug-eluting nanoparticles for image-guided thermo-chemotherapy

Biomaterials. 2018 Oct:180:240-252. doi: 10.1016/j.biomaterials.2018.07.028. Epub 2018 Jul 19.

Authors

Guru Karthikeyan Thirunavukkarasu¹, Kondareddy Cherukula², Hwangjae Lee¹, Yong Yeon Jeong³, In-Kyu Park⁴, Jae Young Lee⁵

Affiliations

¹ School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 500-712, Republic of Korea.
² Department of Biomedical Science and BK21 PLUS Centre for Creative Biomedical Scientists, Chonnam National University Medical School, Gwangju 61469, Republic of Korea.
³ Department of Radiology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju 61469, Republic of Korea.
⁴ Department of Biomedical Science and BK21 PLUS Centre for Creative Biomedical Scientists, Chonnam National University Medical School, Gwangju 61469, Republic of Korea. Electronic address: pik96@chonnam.ac.kr.
⁵ School of Materials Science and Engineering and Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 500-712, Republic of Korea. Electronic address: jaeyounglee@gist.ac.kr.

PMID: 30055399
DOI: 10.1016/j.biomaterials.2018.07.028

Abstract

Multifunctional nanoparticles integrating cancer cell imaging and treatment modalities into a single platform are recognized as a promising approach; however, their development currently remains a challenge. In this study, we synthesized magnetic field-inducible drug-eluting nanoparticles (MIDENs) by embedding superparamagnetic iron oxide nanoparticles (Fe₃O₄; SPIONs) and cancer therapeutic drugs (doxorubicin; DOX) in a temperature-responsive poly (lactic-co-glycolic acid) (PLGA) nanomatrix. Application of an external alternating magnetic field (AMF) generated heat above 42 °C and subsequent transition of the PLGA polymer matrix (T_g = 42-45 °C) from the glassy to the rubbery state, facilitating the controlled release of the loaded DOX, ultimately allowing for simultaneous hyperthermia and local heat-triggered chemotherapy for efficient dual cancer treatment. The average size of the synthesized MIDENs was 172.1 ± 3.20 nm in diameter. In vitro studies showed that the MIDENs were cytocompatible and especially effective in destroying CT26 colon cancer cells with AMF application. In vivo studies revealed that the MIDENs enabled enhanced T₂ contrast magnetic resonance imaging and a significant suppression of malignant tumor growth under an AMF. Our multifunctional MIDENs, composed of biocompatible substances and therapeutic/imaging modalities, will be greatly beneficial for cancer image-guided thermo-chemotherapy applications.

Keywords: Cancer treatment; Magnetic nanoparticles; Nanomedicine; Responsive material; Theragnostics.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Cell Survival / drug effects
Doxorubicin / chemistry*
Doxorubicin / pharmacology*
Drug Delivery Systems / methods*
Humans
Hyperthermia, Induced
Magnetic Fields*
Magnetite Nanoparticles / chemistry*

Substances

Magnetite Nanoparticles
Doxorubicin