Elevation in histamine and tryptase following exercise in patients with mastocytosis

Joseph M Kulinski; Dean D Metcalfe; Michael L Young; Yun Bai; Yuzhi Yin; Robin Eisch; Linda M Scott; Hirsh D Komarow

doi:10.1016/j.jaip.2018.07.008

Elevation in histamine and tryptase following exercise in patients with mastocytosis

J Allergy Clin Immunol Pract. 2019 Apr;7(4):1310-1313.e2. doi: 10.1016/j.jaip.2018.07.008. Epub 2018 Jul 23.

Authors

Joseph M Kulinski¹, Dean D Metcalfe¹, Michael L Young², Yun Bai¹, Yuzhi Yin¹, Robin Eisch¹, Linda M Scott¹, Hirsh D Komarow³

Affiliations

¹ Mast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
² Clinical Research Directorate/Clinical Monitoring Research Program, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, Md.
³ Mast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. Electronic address: komarowh@niaid.nih.gov.

Abstract

Patients with mastocytosis exhibit an increase in serum levels of mast cell-related mediators with exercise and therefore should be guided regarding management of mast cell-associated symptoms to improve safety and quality of life.

Publication types

Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

MeSH terms

Adult
Case-Control Studies
Exercise / physiology*
Female
Histamine / metabolism*
Humans
Male
Mastocytosis / metabolism*
Mastocytosis / physiopathology
Middle Aged
Tryptases / metabolism*
Urticaria / metabolism
Urticaria / physiopathology
Young Adult

Substances

Histamine
Tryptases

Abstract

Publication types

MeSH terms

Substances

Grants and funding