Interactive effects of age and respiratory virus on severe lower respiratory infection

Epidemiol Infect. 2018 Oct;146(14):1861-1869. doi: 10.1017/S0950268818002017. Epub 2018 Jul 26.

Abstract

We investigated risk factors for severe acute lower respiratory infections (ALRI) among hospitalised children 8 months were at greater risk from influenza-associated ICU admissions and long hospital stay. Children with ADV had increased LOS across all ages. In the first 2 years of life, the effects of different viruses on ALRI severity varies with age. Our findings help to identify specific ages that would most benefit from virus-specific interventions such as vaccines and antivirals.

Keywords: ADV adenovirus; ALRI acute lower respiratory infection; ICU intensive care unit admission; LOS hospital length of stay; RSV respiratory syncytial virus; children; respiratory virus; severe ALRI.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acute Disease / epidemiology
  • Age Factors
  • Female
  • Hospitalization / statistics & numerical data*
  • Humans
  • Infant
  • Infant, Newborn
  • Intensive Care Units, Neonatal
  • Intensive Care Units, Pediatric
  • Male
  • New Zealand / epidemiology
  • Respiratory Tract Infections / epidemiology*
  • Respiratory Tract Infections / virology
  • Risk Factors
  • Virus Physiological Phenomena