Sesquiterpenoids with cytotoxicity from heartwood of Dalbergia odorifera

J Asian Nat Prod Res. 2019 Oct;21(10):954-960. doi: 10.1080/10286020.2018.1490727. Epub 2018 Jul 26.

Abstract

Two new sesquiterpenoids, named dalodorin A (1) and dalodorin B (2), together with four known sesquiterpenoids, were isolated from the heartwood of Dalbergia odorifera. Their structures were elucidated on the basis of spectroscopic analysis including 1D and 2D NMR techniques and HR-ESI-MS. Evaluation of the isolated compounds for cytotoxicity against two human cancer cell lines (Hela and HepG-2) showed moderate activities (25.22-60.45 μM).

Keywords: Leguminosae; anti-tumor; heartwood; sesquiterpenoids.

MeSH terms

  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Survival / drug effects
  • Dalbergia / chemistry*
  • Drug Screening Assays, Antitumor
  • HeLa Cells
  • Hep G2 Cells
  • Humans
  • Molecular Structure
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology*
  • Wood / chemistry*

Substances

  • Antineoplastic Agents, Phytogenic
  • Plant Extracts
  • Sesquiterpenes