We aimed to evaluate the association between occupational stress and PCOS risk in a Chinese population and whether insulin resistance mediates the association. A total of 366 patients with PCOS and 325 controls were included in this study. Three logistic regression analyzes were applied in statistical analysis. In the first logistic regression analysis, the occupational stress significantly influenced development of PCOS (cumulative R2 = 0.737). In model 2, the environmental factors cumulatively accounted for 4.2% of the variance in PCOS risk. In model 3, which contained HOMA-IR, the R2 of HOMA-IR to PCOS risk was as high as 0.41, but the R2 of occupational stress reduced to 0.22. HOMA-IR became the main risk factor for PCOS. SEM model showed that ORQ, PSQ and PRQ had a direct and indirect effect on PCOS, and the indirect effect was through HOMA-IR. Occupational stress has a direct and indirect relationship with PCOS, which is mediated by HOMA-IR.
摘要 本研究旨在评估职业压力与PCOS患病风险在中国人群中的相关性, 以及胰岛素抵抗是否介导该相关性的形成。共纳入PCOS患者336名和对照组325名女性参与研究。统计分析采用三种Logistic回归分析。第一种Logistic回归模型表明, 职业压力对PCOS的发展有显著影响（累积R2=0.737）。Logistic回归模型2分析表明, 在PCOS风险中, 环境因素累计占4.2%。Logistic回归模型模型3中加入HOMA-IR作为变量, 结果显示, PCOS发生风险与HOMA-IR的相关性R2高达0.41, 但与职业压力的相关性R2则降至0.22。HOMA-IR成为PCOS发生相关的主要因素。SEM结果显示, ORQ, PSQ和PRQ结果对PCOS具有直接或间接作用, 且间接作用是由HOMA-IR介导。职业紧张与PCOS患病风险有直接和间接的相关性, 且该相关性受HOMA-IR影响。.
Keywords: Occupational stress; insulin resistance; polycystic ovary syndrome.