Evaluation of a multi-slice spiral computed tomography perfusion for the prediction of the recurrence of gastric cancer

Future Oncol. 2018 Aug;14(19):1953-1963. doi: 10.2217/fon-2016-0541. Epub 2018 Jul 25.

Abstract

Aim: The study aimed to elucidate the value of multislice spiral computed tomography (MSCT) perfusion for the early prediction of gastric cancer (GC) recurrence.

Methods: MSCT perfusion scans were performed to obtain values pertaining to blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability surface (PS). Logistic regression analysis was employed to evaluate the risk factors of postoperative recurrence in GC.

Results: The maximum diameter of GC has a positive relationship with PS. The maximum enhancement of GC was positively correlated with BF, blood volume and PS. PS, BF, vascular thrombus and Tumor, Node, Metastasis staging were found to be significant risk factors in relation to the recurrence of GC (p = 0.006, p = 0.002, p < 0.001).

Conclusion: MSCT perfusion is strongly correlated with postoperative recurrence of GC, and PS and BF values, vascular thrombus and Tumor, Node, Metastasis staging were discovered as being prominent factors influencing the recurrence of GC.

Keywords: Tumor, Node, Metastasis; blood volume; gastric cancer; multi-slice spiral computed tomography; perfusion parameter; recurrence; vascular thrombus; blood flow.

MeSH terms

  • Aged
  • Blood Flow Velocity
  • Blood Volume Determination
  • Female
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Neoplasm Recurrence, Local / blood*
  • Neoplasm Recurrence, Local / complications
  • Neoplasm Recurrence, Local / diagnostic imaging
  • Neoplasm Recurrence, Local / surgery
  • Neovascularization, Pathologic / blood
  • Neovascularization, Pathologic / diagnostic imaging
  • Neovascularization, Pathologic / pathology
  • Postoperative Complications / blood*
  • Postoperative Complications / diagnostic imaging
  • Postoperative Complications / pathology
  • Risk Factors
  • Stomach Neoplasms / blood*
  • Stomach Neoplasms / complications
  • Stomach Neoplasms / diagnostic imaging
  • Stomach Neoplasms / surgery
  • Tomography, Spiral Computed*