Resting State fMRI in Rodents

Curr Protoc Neurosci. 2018 Apr;83(1):e45. doi: 10.1002/cpns.45.

Abstract

Resting state functional MRI (fMRI) and functional connectivity are widely applied in humans to examine the role of brain networks in normal function and dysfunction. A similar approach can be taken in rodents, either to obtain translational measures in models of brain disorders or to more carefully examine the neurophysiological underpinnings of the networks. A protocol for resting state functional connectivity in the anesthetized rat, from animal setup to data acquisition to possible pipelines for data analysis, is described. © 2018 by John Wiley & Sons, Inc.

Keywords: MRI; functional connectivity; rat; resting state fMRI.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Brain / physiology*
  • Brain Mapping*
  • Image Processing, Computer-Assisted*
  • Magnetic Resonance Imaging / methods
  • Models, Animal
  • Rats
  • Rest / physiology*
  • Rodentia