Detecting Demyelination by PET: The Lesion as Imaging Target

Mol Imaging. 2018 Jan-Dec:17:1536012118785471. doi: 10.1177/1536012118785471.

Abstract

Noninvasive imaging of demyelination and remyelination is critical for diagnosis and clinical management of demyelinating diseases. Positron emission tomography (PET) has the potential to complement magnetic resonance imaging (MRI) by providing a quantitative measure specific to demyelination. In Brugarolas et al's study 1 , we describe the development of the first PET tracer for voltage-gated K+ channels based on a clinically approved drug for multiple sclerosis that can be used for imaging demyelination in animal models.

Keywords: advances in PET/SPECT probes; imaging in neuroscience; molecular imaging of neuro-degenerative diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Axons / metabolism
  • Demyelinating Diseases / diagnosis*
  • Demyelinating Diseases / diagnostic imaging*
  • Humans
  • Magnetic Resonance Imaging
  • Positron-Emission Tomography / methods*
  • Potassium Channels / metabolism

Substances

  • Potassium Channels