Lung cancer is one of the most important malignant tumors of human health and life in the world, and is the leading cause of death in the world. At present, it is believed that it is caused by many factors. Circular RNA (circRNA), as a class of non-coding RNA family, has covalently closed loop structure. CircRNA is abundant in different cells. CircRNAs due to the special structure, with a high degree of specificity, conservation and stability, may have a potential clinical value in the development of lung cancer. The biological function of circRNA is multi-faceted, including miRNA sponge, transcriptional and alternative splicing, protein coding , and so on. Currently, the role and mechanism of circRNA in lung cancer is not very clear. In this paper, the characteristics, function, mechanism and the role of circRNAs in the occurrence and development of lung cancer are reviewed. .
【中文题目：环状RNA与肺癌的研究进展】 【中文摘要：肺癌是目前世界上对人类健康和生命威胁最主要的恶性肿瘤之一，也是全世界目前因恶性肿瘤导致死亡的第一病因。目前认为其发生由很多因素共同作用的结果。环状RNA（circular RNA, circRNA）作为非编码RNA家族成员，具有特征性的共价闭合环结构，在各种生物中广泛表达。circRNA由于特殊的结构，具有高度的特异性、保守性和稳定性，可能在肺癌的发生发展过程中，具有潜在的临床价值。circRNA的主要功能是作为海绵吸附miRNA发挥转录调控作用，同时还具有调控可变剪接、编码蛋白等作用。目前circRNA在肺癌中的作用及机制并不是很清楚，本文就circRNA的特征、功能、作用机制以及在肺癌发生、发展中的作用进行综述。 】 【中文关键词：环状RNA；肺肿瘤；基因表达；调控】.
Keywords: Circular RNA; Gene expression; Lung neoplasms; Regulation.