Abstract
X-ray analysis and total synthesis of 1 unambiguously confirmed pleofingin A's absolute configuration. The total synthesis was achieved by convergent assembly of three fragments (12, 14, and 18). This synthetic approach provides access to derivatives of 1 to search for antifungal agents that will be more effective in clinical use.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / chemical synthesis*
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Crystallization
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Cyclization
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Depsipeptides / chemical synthesis*
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Glycosphingolipids / chemistry*
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Hexosyltransferases / antagonists & inhibitors*
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Inhibitory Concentration 50
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Molecular Structure
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Saccharomyces cerevisiae / drug effects
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Structure-Activity Relationship
Substances
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Antifungal Agents
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Depsipeptides
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Glycosphingolipids
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inositolphosphorylceramide
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Hexosyltransferases
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phosphatidylinositol-ceramide phosphoinositol transferase