The Emerging Role of Gas Plasma in Oncotherapy

Xiaofeng Dai; Kateryna Bazaka; Derek J Richard; Erik Rik W Thompson; Kostya Ken Ostrikov

doi:10.1016/j.tibtech.2018.06.010

The Emerging Role of Gas Plasma in Oncotherapy

Trends Biotechnol. 2018 Nov;36(11):1183-1198. doi: 10.1016/j.tibtech.2018.06.010. Epub 2018 Jul 20.

Authors

Xiaofeng Dai¹, Kateryna Bazaka², Derek J Richard³, Erik Rik W Thompson⁴, Kostya Ken Ostrikov²

Affiliations

¹ Wuxi School of Medicine, Jiangnan University, Wuxi, China; School of Biotechnology, Jiangnan University, Wuxi, China. Electronic address: xiaofeng.dai@jiangnan.edu.cn.
² School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, Queensland 4059, Australia; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia.
³ Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia; Translational Research Institute, Woolloongabba 4102, Queensland, Australia; University of Melbourne Department of Surgery, St Vincent's Hospital, Melbourne, Victoria 3065, VIC, Australia; School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland 4059, Australia.
⁴ Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia; Translational Research Institute, Woolloongabba 4102, Queensland, Australia; University of Melbourne Department of Surgery, St Vincent's Hospital, Melbourne, Victoria 3065, VIC, Australia; School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland 4059, Australia. Electronic address: e2.thompson@qut.edu.au.

PMID: 30033340
DOI: 10.1016/j.tibtech.2018.06.010

Abstract

Atmospheric pressure gas plasmas are emerging as a promising treatment in cancer that can supplement the existing set of treatment modalities and, when combined with other therapies, enhance their selectivity and efficacy against resistant cancers. With further optimisation in production and administration of plasma treatment, plasma-enabled therapy has a strong potential to mature as a tool for selectively curing highly resistant solid tumours. Although intense preclinical studies have been conducted to exploit the unique traits of plasma as an oncotherapy, few clinical studies are underway. This review identifies types of cancers and patient groups that most likely benefit from plasma oncotherapy, to introduce clinical practitioners to plasma therapy and accelerate the speed of translating plasma for cancer control in clinics.

Keywords: chemotherapy; cold atmospheric plasma; multimodality therapy; oncotherapy; radiotherapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aged
Humans
Pancreatic Neoplasms / therapy*
Plasma Gases / therapeutic use*
Treatment Outcome

Substances

Plasma Gases