Biodegradable Polyvinyl Alcohol Vascular Stents: Structural Model and Mechanical and Biological Property Evaluation

Mei-Chen Lin; Ching-Wen Lou; Jan-Yi Lin; Ting An Lin; Yueh-Sheng Chen; Jia-Horng Lin

doi:10.1016/j.msec.2018.05.030

Biodegradable Polyvinyl Alcohol Vascular Stents: Structural Model and Mechanical and Biological Property Evaluation

Mater Sci Eng C Mater Biol Appl. 2018 Oct 1:91:404-413. doi: 10.1016/j.msec.2018.05.030. Epub 2018 May 11.

Authors

Mei-Chen Lin¹, Ching-Wen Lou², Jan-Yi Lin¹, Ting An Lin¹, Yueh-Sheng Chen³, Jia-Horng Lin⁴

Affiliations

¹ Laboratory of Fiber Application and Manufacturing, Department of Fiber and Composite Materials, Feng Chia University, Taichung City 40724, Taiwan.
² School of Textiles, Tianjin Polytechnic University, Tianjin 300387, China; Department of Chemical Engineering and Materials, Ocean College, Minjiang University, Fujian 350108, China; Department of Bioinformatics and Medical Engineering, Asia University, Taichung 41354, Taiwan; College of Textile and Clothing, Qingdao University, Shangdong 266071, China.
³ Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung City 40402, Taiwan.
⁴ Department of Chemical Engineering and Materials, Ocean College, Minjiang University, Fujian 350108, China; College of Textile and Clothing, Qingdao University, Shangdong 266071, China; Department of Fiber and Composite Materials, Feng Chia University, Taichung City 40724, Taiwan; Innovation Platform of Intelligent and Energy-Saving Textiles, School of Textiles, Tianjin Polytechnic University, China; School of Chinese Medicine, China Medical University, Taichung 40402, Taiwan; Department of Fashion Design, Asia University, Taichung 41354, Taiwan. Electronic address: jhlin@fcu.edu.tw.

PMID: 30033271
DOI: 10.1016/j.msec.2018.05.030

Abstract

This study proposes structural models of biodegradable vascular stents. One, two, or three plies of biodegradable polyvinyl alcohol (PVA) yarns are combined and twisted with twist factors of 2, 3, 4, 5, and 6 to form one-, two-, and three-ply PVA twisted yarns. The braided, warp-knitted, and weft-knitted PVA vascular stents are composed of PVA twisted yarns by using a braider, a warp knitting machine, and a weft knitting machine. The formation and mechanical properties of PVA vascular stents are evaluated, and the biological properties are examined in terms of biocompatibility through in vitro assay and subcutaneous embedding using in vivo assay. Test results indicate that the compression strength of PVA vascular stents is improved when using PVA twisted yarns containing a high number of plies and twist factor. Specifically, weft-knitted PVA vascular stents exhibit the optimal compression strength. PVA vascular stents treated with chemical cross-linking show weight loss lower than 3% after immersion in PBS solution for 30 days. Moreover, the antibacterial test and cell culture results suggest that PVA vascular stents are nontoxic and biocompatible. Subcutaneous embedding results show that PVA vascular stents retain intact formation when subcutaneously embedded in vivo for 28 days, indicating their good biological property. PVA vascular stents are suitable candidates for tissue engineering applications.

Keywords: Biocompatibility; Chemical cross-linking; Formation; Polyvinyl alcohol; Tissue engineering.

MeSH terms

Animals
Anti-Bacterial Agents / pharmacology
Biocompatible Materials / chemistry*
Blood Vessels / physiology*
Cell Line
Colony Count, Microbial
Escherichia coli / drug effects
Materials Testing / methods*
Mechanical Phenomena*
Mice
Microbial Sensitivity Tests
Polyvinyl Alcohol / chemistry*
Rats
Staphylococcus aureus / drug effects
Stents*
Subcutaneous Tissue / drug effects

Substances

Anti-Bacterial Agents
Biocompatible Materials
Polyvinyl Alcohol