Role of two-component regulatory systems in the virulence of Streptococcus suis

Chengkun Zheng; Lingzhi Li; Haojie Ge; Hongmei Meng; Yang Li; Weicheng Bei; Xiaohui Zhou

doi:10.1016/j.micres.2018.07.002

Role of two-component regulatory systems in the virulence of Streptococcus suis

Microbiol Res. 2018 Sep:214:123-128. doi: 10.1016/j.micres.2018.07.002. Epub 2018 Jul 7.

Authors

Chengkun Zheng¹, Lingzhi Li², Haojie Ge², Hongmei Meng², Yang Li², Weicheng Bei³, Xiaohui Zhou⁴

Affiliations

¹ Jiangsu Key Laboratory of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety/Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, The Ministry of Education of China, Yangzhou University, Yangzhou, 225009, China; State Key Laboratory of Agricultural Microbiology/The Cooperative Innovation Center for Sustainable Pig Production, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.
² Jiangsu Key Laboratory of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety/Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, The Ministry of Education of China, Yangzhou University, Yangzhou, 225009, China.
³ State Key Laboratory of Agricultural Microbiology/The Cooperative Innovation Center for Sustainable Pig Production, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China. Electronic address: beiwc@mail.hzau.edu.cn.
⁴ Jiangsu Key Laboratory of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety/Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, The Ministry of Education of China, Yangzhou University, Yangzhou, 225009, China; Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT, 06269, USA. Electronic address: 006525@yzu.edu.cn.

PMID: 30031474
DOI: 10.1016/j.micres.2018.07.002

Abstract

Streptococcus suis is an important zoonotic pathogen that causes severe infections and great economic losses worldwide. Understanding how this pathogen senses and responds to environmental signals during the infectious process can offer insight into its pathogenesis and may be helpful in the development of drug targets. Two-component regulatory systems (TCSs) play an essential role in this environmental response. In S. suis, at least 15 groups of TCSs have been predicted. Among them, several have been demonstrated to be involved in virulence and/or stress response. In this review, we discuss the progress in the study of TCSs in S. suis, focusing on the role of these systems in the virulence of this bacterium.

Keywords: Streptococcus suis; Two-component regulatory systems; Virulence.

Publication types

Review

MeSH terms

Adaptation, Physiological
Gene Expression Regulation, Bacterial*
Gene Regulatory Networks*
Signal Transduction*
Streptococcal Infections / microbiology*
Streptococcus suis / growth & development*
Streptococcus suis / pathogenicity*
Virulence
Virulence Factors / biosynthesis*

Substances

Virulence Factors