The process of building an organ, appendage, or organism requires the precise coordination of cells in space and time. Regeneration of those same tissues adds an additional element of complexity, emerging from the chaos of disease or injury to build a mass of progenitors from mature tissue. Translating insights from natural examples of tissue regeneration into engineered regenerative therapies requires a deep understanding of the journey of a cell directly following injury to its contribution to functional, scaled replacement tissue. Here we step through the chronological phases of regeneration and highlight emerging work that brings us closer to elucidating the unique intrinsic and extrinsic properties of cells during epimorphic regeneration.
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