Nerve growth factor as an important possible component of novel therapy for cancer, diabetes and cardiovascular diseases

Karol P Steckiewicz; Ewelina Barcińska; Michał Woźniak

Nerve growth factor as an important possible component of novel therapy for cancer, diabetes and cardiovascular diseases

Cell Mol Biol (Noisy-le-grand). 2018 Jun 30;64(9):16-23.

Authors

Karol P Steckiewicz¹, Ewelina Barcińska¹, Michał Woźniak¹

Affiliation

¹ Chair and Department of Medical Chemistry, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.

PMID: 30030957

Abstract

Nerve growth factor (NGF) is protein discovered by Rita Levi Montalcini in the 1950s. It plays a crucial role in the development of nervous system. NGF may be produced by a variety of cells even beyond nervous system. NGF modulate cell metabolism by binding to p75NTR and TrkA receptors. NGF is involved in psychological processes and may be the possible therapeutical agent for diabetes, cancer and cardiovascular diseases, which will be described in the article.

Keywords: Cancer; Cardiovascular diseases.; Diabetes; Nerve growth factor.

Publication types

Review

MeSH terms

Diabetes Mellitus, Type 2 / drug therapy*
Diabetes Mellitus, Type 2 / pathology
Heart Diseases / diet therapy*
Heart Diseases / pathology
Humans
Neoplasms / drug therapy*
Neoplasms / pathology
Nerve Growth Factor / metabolism
Nerve Growth Factor / therapeutic use*
Receptor, trkA / metabolism
Receptors, Nerve Growth Factor / metabolism
Signal Transduction

Substances

Receptors, Nerve Growth Factor
Nerve Growth Factor
Receptor, trkA