PGC-1α driven mitochondrial biogenesis in stromal cells underpins mitochondrial trafficking to leukemic blasts

Leukemia. 2018 Sep;32(9):2073-2077. doi: 10.1038/s41375-018-0221-y. Epub 2018 Jul 20.

¹ Department of Molecular Haematology, Norwich Medical School, The University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
² Haematopathology and Oncology Diagnostic Service, Addenbrooke's Hospital, Hills Rd, Cambridge, CB2 0QQ, UK.
³ Department of Trauma and Orthopaedic Surgery, Norfolk and Norwich University Hospitals NHS Trust, Colney Lane, Norwich, NR4 7UY, UK.
⁴ Department of Haematology, Norfolk and Norwich University Hospitals NHS Trust, Colney Lane, Norwich, NR4 7UY, UK.
⁵ Department of Molecular Haematology, Norwich Medical School, The University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK. k.bowles@uea.ac.uk.
⁶ Department of Haematology, Norfolk and Norwich University Hospitals NHS Trust, Colney Lane, Norwich, NR4 7UY, UK. k.bowles@uea.ac.uk.
⁷ Department of Molecular Haematology, Norwich Medical School, The University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK. s.rushworth@uea.ac.uk.

No abstract available

Publication types

Biomarkers, Tumor
Cell Respiration / genetics
Gene Expression Regulation, Leukemic
Humans
Leukemia / etiology*
Leukemia / metabolism*
Leukemia / pathology
Mitochondria / genetics*
Mitochondria / metabolism*
Mutation
Neoplasm Staging
Organelle Biogenesis*
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / genetics*
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism
Stromal Cells / metabolism*
Tumor Microenvironment