Organic electrochromic timer for enzymatic skin patches

Hiroyuki Kai; Wataru Suda; Shotaro Yoshida; Matsuhiko Nishizawa

doi:10.1016/j.bios.2018.07.013

Organic electrochromic timer for enzymatic skin patches

Biosens Bioelectron. 2019 Jan 1:123:108-113. doi: 10.1016/j.bios.2018.07.013. Epub 2018 Jul 10.

Authors

Hiroyuki Kai¹, Wataru Suda¹, Shotaro Yoshida¹, Matsuhiko Nishizawa²

Affiliations

¹ Department of Finemechanics, Tohoku University, 6-6-1 Aramaki Aoba, Sendai 980-8579, Japan.
² Department of Finemechanics, Tohoku University, 6-6-1 Aramaki Aoba, Sendai 980-8579, Japan. Electronic address: nishizawa@biomems.mech.tohoku.ac.jp.

PMID: 30029842
DOI: 10.1016/j.bios.2018.07.013

Abstract

A totally organic and disposable electrochromic timer integrated with an enzymatic electrode and powered by biofuel cells is developed. The cathode of the self-powered electrochromic timer consists of a composite electrochromic film of poly(3,4-ethylenedioxythiophene) (PEDOT) and polyurethane (PU), while the anode is made up of a fructose dehydrogenase (FDH) enzymatic electrode. The electrochromic changes over time (up to 100 min) can be displayed in the device, and the speed of color change can be controlled by changing the resistance between the anode and the cathode. Automatic activation of the timer after placement on a skin is achieved by integrating a porous microneedle array. The electrochromic timer would be used along with a skin patch as a time-lapse display of medical and cosmetic treatments.

Keywords: Biofuel cell; Electrochromism; Skin patch; Transdermal drug delivery; Wound healing.

MeSH terms

Bioelectric Energy Sources
Biosensing Techniques*
Bridged Bicyclo Compounds, Heterocyclic / chemistry
Electrodes
Fructose / chemistry*
Needles
Oxidoreductases / chemistry*
Polymers / chemistry
Polyurethanes / chemistry
Skin / chemistry*

Substances

Bridged Bicyclo Compounds, Heterocyclic
Polymers
Polyurethanes
poly(3,4-ethylene dioxythiophene)
Fructose
Oxidoreductases