Microchip gas chromatography columns, interfacing and performance

Abhijit Ghosh; Carlos R Vilorio; Aaron R Hawkins; Milton L Lee

doi:10.1016/j.talanta.2018.04.088

Microchip gas chromatography columns, interfacing and performance

Talanta. 2018 Oct 1:188:463-492. doi: 10.1016/j.talanta.2018.04.088. Epub 2018 May 2.

Authors

Abhijit Ghosh¹, Carlos R Vilorio², Aaron R Hawkins², Milton L Lee³

Affiliations

¹ Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA.
² Department of Electrical and Computer Engineering, Brigham Young University, Provo, UT 84602, USA.
³ Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA. Electronic address: milton_lee@byu.edu.

PMID: 30029402
DOI: 10.1016/j.talanta.2018.04.088

Abstract

Almost four decades of investigations have opened up many avenues to explore the production and utilization of planar (i.e., microchip) gas chromatographic columns. However, there remain many practical constraints that limit their widespread commercialization and use. The main challenges arise from non-ideal column geometries, dead volume issues and inadequate interfacing technologies, which all affect both column performance and range of applications. This review reflects back over the years on the extensive developments in the field, with the goal to stimulate future creative approaches and increased efforts to accelerate microchip gas chromatography development toward reaching its full potential.

Keywords: Column performance; Gas chromatography; Interfacing technology; Microchip; Microfabrication.

Publication types

Review