A novel design of a polynuclear co-delivery system for safe and efficient cancer therapy

Lei Xing; Jia-Liang Zhang; Tian-Jiao Zhou; Yu-Jing He; Peng-Fei Cui; Jia-Hui Gong; Minjie Sun; Jin-Jian Lu; Zhangjian Huang; Liang Jin; Hu-Lin Jiang

doi:10.1039/c8cc03720e

A novel design of a polynuclear co-delivery system for safe and efficient cancer therapy

Chem Commun (Camb). 2018 Aug 14;54(63):8737-8740. doi: 10.1039/c8cc03720e. Epub 2018 Jul 20.

Authors

Affiliations

¹ State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China. jianghulin3@gmail.com and Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, China Pharmaceutical University, Nanjing, 210009, China and Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, China and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing, 210009, China.
² State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China. jianghulin3@gmail.com and Department of Pharmacy, Dong Fang Hospital (Fuzhou General Hospital), Medical College of Xiamen University, Xiamen University, Fouzhou 350025, China.
³ State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China. jianghulin3@gmail.com.
⁴ State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.
⁵ State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China. jianghulin3@gmail.com and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing, 210009, China.
⁶ State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China. jianghulin3@gmail.com and School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China. liangjin1975@cpu.edu.cn.

PMID: 30027958
DOI: 10.1039/c8cc03720e

Abstract

We report a novel and easy-to-fabricate polynuclear nanoparticle based on the collaborative re-assembly of nanoparticles as a robust chemogene co-delivery platform. Specifically, the polynuclear nanoparticle carrying DOX and siBcl-2 exerts remarkable co-delivery efficiency, increases tumour cell apoptosis and inhibits tumour cell proliferation in vitro and in vivo.

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Apoptosis / drug effects
Cell Proliferation / drug effects
Dose-Response Relationship, Drug
Doxorubicin / chemistry
Doxorubicin / pharmacology*
Drug Delivery Systems*
Drug Design*
Drug Screening Assays, Antitumor
Humans
MCF-7 Cells
Nanoparticles / chemistry*
Particle Size
Polymers / chemistry*
RNA, Small Interfering / chemistry
RNA, Small Interfering / pharmacology*
Structure-Activity Relationship
Surface Properties

Substances

Antineoplastic Agents
Polymers
RNA, Small Interfering
Doxorubicin