Mouse Models of Cardiac Arrhythmias

Dobromir Dobrev; Xander H T Wehrens

doi:10.1161/CIRCRESAHA.118.313406

Mouse Models of Cardiac Arrhythmias

Circ Res. 2018 Jul 20;123(3):332-334. doi: 10.1161/CIRCRESAHA.118.313406.

Authors

Dobromir Dobrev¹, Xander H T Wehrens²

Affiliations

¹ From the Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Germany (D.D.).
² Cardiovascular Research Institute, Departments of Molecular Physiology and Biophysics, Medicine (Cardiology), Pediatrics (Cardiology), and Center for Space Medicine, Baylor College of Medicine, Houston, TX (X.H.T.W.). wehrens@bcm.edu.

Abstract

Mouse models have been invaluable for delineating the contributions of specific genes and signaling pathways to the pathogenesis of cardiac arrhythmias. Considering that there are important differences between mice and humans, here we discuss the strengths and limitations of mouse models of cardiac arrhythmias.

Keywords: atrial fibrillation; cell lines; gene targeting; mice; oocytes.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Arrhythmias, Cardiac / genetics*
Arrhythmias, Cardiac / metabolism
Arrhythmias, Cardiac / physiopathology
Arrhythmias, Cardiac / therapy
Disease Models, Animal*
Heart / physiology
Heart / physiopathology
Mice
Myocardium / metabolism
Translational Research, Biomedical / methods

Abstract

Publication types

MeSH terms

Grants and funding