Abstract
Novel D-π-A-π-D probes were investigated for the detection of Aβ plaques and NFTs. The probes displayed remarkable optical properties, and DADNIR-2 possessed high affinity towards Tau and Aβ aggregates (Kd = 0.41 nM and 1.04 nM, respectively) with certain selectivity. DADNIR-2 could penetrate the BBB and label Aβ plaques in vivo.
MeSH terms
-
Alzheimer Disease / metabolism*
-
Amyloid beta-Peptides / analysis*
-
Amyloid beta-Peptides / metabolism
-
Animals
-
Humans
-
Infrared Rays*
-
Male
-
Mice
-
Mice, Inbred C57BL
-
Mice, Transgenic
-
Molecular Probes / analysis*
-
Molecular Probes / chemical synthesis
-
Molecular Probes / chemistry
-
Molecular Structure
-
Optical Imaging*
-
Protein Aggregates
-
tau Proteins / analysis*
-
tau Proteins / metabolism
Substances
-
Amyloid beta-Peptides
-
Molecular Probes
-
Protein Aggregates
-
tau Proteins