Novel D-A-D based near-infrared probes for the detection of β-amyloid and Tau fibrils in Alzheimer's disease

Chem Commun (Camb). 2018 Aug 2;54(63):8717-8720. doi: 10.1039/c8cc05259j.

Abstract

Novel D-π-A-π-D probes were investigated for the detection of Aβ plaques and NFTs. The probes displayed remarkable optical properties, and DADNIR-2 possessed high affinity towards Tau and Aβ aggregates (Kd = 0.41 nM and 1.04 nM, respectively) with certain selectivity. DADNIR-2 could penetrate the BBB and label Aβ plaques in vivo.

MeSH terms

  • Alzheimer Disease / metabolism*
  • Amyloid beta-Peptides / analysis*
  • Amyloid beta-Peptides / metabolism
  • Animals
  • Humans
  • Infrared Rays*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Molecular Probes / analysis*
  • Molecular Probes / chemical synthesis
  • Molecular Probes / chemistry
  • Molecular Structure
  • Optical Imaging*
  • Protein Aggregates
  • tau Proteins / analysis*
  • tau Proteins / metabolism

Substances

  • Amyloid beta-Peptides
  • Molecular Probes
  • Protein Aggregates
  • tau Proteins