Overview of sulfonamide biodegradation and the relevant pathways and microorganisms

Abstract

Sulfonamide antibiotics have aroused increasing concerns due to their ability to enhance the resistance of pathogenic bacteria and promote the spread of antibiotic resistance. Biodegradation plays an important role in sulfonamide dissipation in both natural and engineered ecosystems. In this article, we provided an overview of sulfonamide biodegradation in different systems and summarized the relevant sulfonamide-degrading species and metabolic pathways. The removal of sulfonamides depends on a variety of factors, such as the type and initial concentration of sulfonamides, the properties of water or soil, and treatment process. The removal efficiency of sulfonamides by engineered ecosystems can be improved by optimizing their operating conditions. Much higher sulfonamide removal was also observed in upgraded or advanced treatment systems than in conventional activated sludge systems. Ammonia oxidation might promote sulfonamide biodegradation. In addition, sulfonamide-degraders from different bacterial genera have been isolated and classified, but no bioaugmentation practice has been reported. Different pathways have been detected in sulfonamide biodegradation. Further efforts will be necessary to elucidate in-situ degraders and the metabolic pathways and functional genes of sulfonamide biodegradation.

Keywords: Antibiotics; Biodegradation; Metabolic pathway; Microbial community; Sulfonamides.