Getting a Taste for Parasites in the Gut

P'ng Loke; Ken Cadwell

doi:10.1016/j.immuni.2018.07.002

Getting a Taste for Parasites in the Gut

Immunity. 2018 Jul 17;49(1):16-18. doi: 10.1016/j.immuni.2018.07.002.

Authors

P'ng Loke¹, Ken Cadwell²

Affiliations

¹ Department of Microbiology, New York University School of Medicine, New York, NY, USA. Electronic address: png.loke@nyumc.org.
² Department of Microbiology, New York University School of Medicine, New York, NY, USA; Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY, USA. Electronic address: ken.cadwell@med.nyu.edu.

PMID: 30021142
DOI: 10.1016/j.immuni.2018.07.002

Abstract

How type 2 immune responses are initiated is obscure. Nadjsombati et al. (2018), along with two other studies (Lei et al., 2018; Schneider et al., 2018), show that tuft cells can initiate type 2 responses by recognizing the metabolite succinate produced by intestinal parasites.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

Animals
Diabetes Mellitus, Type 2*
Intestines
Parasites*
Succinic Acid
Taste

Substances

Succinic Acid